Blind man’s vision partially restored with new gene therapy

An ongoing clinical trial seeks to test the safety of the gene therapy in other patients. “Blind people with different types of neurodegenerative diseases of the photoreceptors and a functioning optic nerve will potentially be eligible for treatment, but it will take time before this therapy can be offered,” said Sahel. In the therapy treatment, scientists took these genes and injected them into the remaining functioning ganglion cells in the retina to make them produce the light-sensitive protein ChrimsonR. Scientists were then able to test him in a lab when the pandemic was at a low point over the summer. While wearing the goggles, the patient was able to perceive, locate, count and touch small objects, including a notebook, a staple box and glass tumblers, placed in front of him on a white table. José-Alain Sahel. / Nature Medicine

Without the goggles, the patient still cannot see. “Adjusting to using the glasses takes time,” said lead researcher Dr. They called the results “remarkable.” 

Behavioral responses and brain activity were simultaneously recorded during the visual test using an EEG. 

Sahel et al. It marks a major milestone in the treatment of genetic blindness. 

In a breakthrough study published this week in the journal Nature Medicine, the man, whose identity was not revealed, was treated with optogenetics therapy, which uses algae proteins to control cells in the eyes. Forty years ago, the man, who resides in France, was diagnosed with retinitis pigmentosa. Scientists hope to test more patients in Paris, Pittsburgh and London as soon as COVID-19 restrictions are lifted and complete their trial by the end of 2025.  “The findings provide proof-of-concept that using optogenetic therapy to partially restore vision is possible,” said co-author Botond Roska. 

The goal of the research is to treat inherited photoreceptor diseases, which are widespread causes of human blindness. First published on May 25, 2021 / 1:04 PM While he could identify the notebook 92% of the time, he could only touch the smaller staple box 36% of the time. 

Using non-invasive electroencephalography (EEG) readings, the team of international scientists found that activity in the visual cortex of his brain changed based on whether or not an object was present — confirming its connection to the retina. Amber light is safer than blue-spectrum light, like that from cell phones and computer screens.During the pandemic lockdown, the patient wore the goggles at home and on walks. Man blind for 40 years partially regains sight with new gene therapy: “A major breakthrough”

By Sophie Lewis

May 25, 2021 / 1:04 PM
/ CBS News

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Blind man invents new rock climbing system

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Scientists for the very first time say they have partially restored the vision of a man who has been blind for 40 years — and they did it using algae proteins. The 58-year-old has had no vision for the last two decades, after his photoreceptors degenerated and could no longer deliver visual information from the eyes to the brain. “Initially, the patient didn’t find the glasses very useful, but after a few months, he started to see the white stripes on a crosswalk and after several training sessions was able to recognize other objects, big and small.”Researchers said it is the first time optogenetic therapy has been used successfully in humans, following more than a decade of research. The rare genetic disorder breaks down fragile photoreceptors, or light-sensing cells, in the retina, and affects up to 1 in 4,000 people worldwide, according to the National Institutes of Health. Helens

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Blind man’s vision partially restored with new gene therapy

Revisiting the 1980 eruption of Mount St. But within a year of the pioneering trial, his sight had been partially restored. Optogenetics, traditionally used by neuroscientists, involves manipulating cells to make them sensitive to light. After about seven months, he was shocked when he noticed the stripes of a crosswalk. cicada infestation coming in 2021? In this case, scientists used it to partially restore the man’s ability to detect light in one of his eyes. “I hope it will be a major breakthrough.” While treatment does not bring the patient close to full vision, it does provide a promising starting point for researchers. Once formed, the proteins could then respond to light and send image signals to the brain. ChrimsonR proteins specifically sense amber light, so researchers developed a special pair of goggles to capture and project images at amber light wavelengths. RP patient performing visual detection tasks by
Institut de la vision on
YouTube

The technique is based on algae proteins that respond to light sources with movement.

Blind man’s vision partially restored with new gene therapy

“Initially, the patient didn’t find the glasses very useful, but after a few months, he started to see the white stripes on a crosswalk and after several training sessions was able to recognize other objects, big and small.”Researchers said it is the first time optogenetic therapy has been used successfully in humans, following more than a decade of research. After about seven months, he was shocked when he noticed the stripes of a crosswalk. Trending News

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Blind man’s vision partially restored with new gene therapy

Revisiting the 1980 eruption of Mount St. cicada infestation coming in 2021? In this case, scientists used it to partially restore the man’s ability to detect light in one of his eyes. Scientists hope to test more patients in Paris, Pittsburgh and London as soon as COVID-19 restrictions are lifted and complete their trial by the end of 2025. But within a year of the pioneering trial, his sight had been partially restored. Optogenetics, traditionally used by neuroscientists, involves manipulating cells to make them sensitive to light. “I hope it will be a major breakthrough.” While treatment does not bring the patient close to full vision, it does provide a promising starting point for researchers. The rare genetic disorder breaks down fragile photoreceptors, or light-sensing cells, in the retina, and affects up to 1 in 4,000 people worldwide, according to the National Institutes of Health. Scientists were then able to test him in a lab when the pandemic was at a low point over the summer. While wearing the goggles, the patient was able to perceive, locate, count and touch small objects, including a notebook, a staple box and glass tumblers, placed in front of him on a white table. Amber light is safer than blue-spectrum light, like that from cell phones and computer screens.During the pandemic lockdown, the patient wore the goggles at home and on walks. / Nature Medicine

Without the goggles, the patient still cannot see. “Adjusting to using the glasses takes time,” said lead researcher Dr. Man blind for 40 years partially regains sight with new gene therapy: “A major breakthrough”

By Sophie Lewis

May 25, 2021 / 1:04 PM
/ CBS News

Blind man invents new rock climbing system

Blind man invents new rock climbing system

05:36

Scientists for the very first time say they have partially restored the vision of a man who has been blind for 40 years — and they did it using algae proteins. They called the results “remarkable.” 

Behavioral responses and brain activity were simultaneously recorded during the visual test using an EEG. 

Sahel et al. The 58-year-old has had no vision for the last two decades, after his photoreceptors degenerated and could no longer deliver visual information from the eyes to the brain. First published on May 25, 2021 / 1:04 PM While he could identify the notebook 92% of the time, he could only touch the smaller staple box 36% of the time. 

Using non-invasive electroencephalography (EEG) readings, the team of international scientists found that activity in the visual cortex of his brain changed based on whether or not an object was present — confirming its connection to the retina. It marks a major milestone in the treatment of genetic blindness. 

In a breakthrough study published this week in the journal Nature Medicine, the man, whose identity was not revealed, was treated with optogenetics therapy, which uses algae proteins to control cells in the eyes. Forty years ago, the man, who resides in France, was diagnosed with retinitis pigmentosa. RP patient performing visual detection tasks by
Institut de la vision on
YouTube

The technique is based on algae proteins that respond to light sources with movement. Once formed, the proteins could then respond to light and send image signals to the brain. ChrimsonR proteins specifically sense amber light, so researchers developed a special pair of goggles to capture and project images at amber light wavelengths. In the therapy treatment, scientists took these genes and injected them into the remaining functioning ganglion cells in the retina to make them produce the light-sensitive protein ChrimsonR. José-Alain Sahel. Helens

What is Brood X, the U.S. An ongoing clinical trial seeks to test the safety of the gene therapy in other patients. “Blind people with different types of neurodegenerative diseases of the photoreceptors and a functioning optic nerve will potentially be eligible for treatment, but it will take time before this therapy can be offered,” said Sahel.  “The findings provide proof-of-concept that using optogenetic therapy to partially restore vision is possible,” said co-author Botond Roska. 

The goal of the research is to treat inherited photoreceptor diseases, which are widespread causes of human blindness.